escape – Communicable Diseases Research

Numerical investigation on indoor environment decontamination after sneezing

재채기 후 실내환경 오염제거 수치조사

Article

Published on 2022-10-012022-09-11
Journal: Environmental research
[Category] COVID19(2023년), SARS, 변종,

Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1

Alpha에서 Omicron BA.1까지 변이체를 교차 중화하는 조상 SARS-CoV-2 균주에 의해 유도된 항체

Article

Published on 2022-08-122022-09-11
Journal: Science Immunology
[Category] Fulltext, SARS, 변종, 진단,

[키워드] ACE2 binding antibodies antibody B cell binding binding site breadth caused Cell Clusters complexes cross-neutralize Defense defined Delta determinant determinants determine disease driven by Efficacy escape Fab FIVE greater highest Host host defense identifying Immune escape immune protection Infection initial memory B memory B cell Mitigation Mutation neutralization neutralization potency neutralize neutralized Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Prevalence RBD real-world data Receptor binding domain recognize recognizing Region SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoV-2 strain sensitivity Specificities specificity spike glycoprotein Spike receptor binding domain Structure structures tested the RBD the SARS-CoV-2 Vaccine vaccine efficacy variant variants variants of concern Viral viral escape viral invasion Wuhan strain
[DOI] 10.1126/sciimmunol.abo3425 PMC 바로가기 [Article Type] Article

T-cell responses to SARS-CoV-2 Omicron spike epitopes with mutations after the third booster dose of an inactivated vaccine

비활성화 백신의 세 번째 추가 접종 후 돌연변이가 있는 SARS-CoV-2 오미크론 스파이크 에피토프에 대한 T 세포 반응

Article

Published on 2022-08-012022-09-11
Journal: Journal of medical virology
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Antibody Response Antibody responses booster dose booster vaccination conserved CoronaVac coronavirus dose elicited enhancement Epitopes escape estimate evaluated Impact Inactivated vaccine individual individuals Infection mononuclear cell mononuclear cells Mutation mutations omicron Omicron variant participant Participants PBMCs peptide peptides Peripheral blood Peripheral blood mononuclear cells Protective respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly spike epitope Spike protein Spike proteins stimulate T-cell T-cell activation T-cell Response T-cell responses the SARS-CoV-2 the spike protein Vaccine vaccine. Vaccines variant virus volunteers weakened were used
[DOI] 10.1002/jmv.27814 PMC 바로가기 [Article Type] Article

Potential linear B-cells epitope change to a helix structure in the spike of Omicron 21L or BA.2 predicts increased SARS-CoV-2 antibodies evasion

Omicron 21L 또는 BA.2의 스파이크에서 나선 구조로의 잠재적 선형 B 세포 에피토프 변화는 SARS-CoV-2 항체 회피 증가를 예측합니다

Article

Published on 2022-08-012022-09-11
Journal: Virology
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

Rhabdomyolysis-Induced AKI (RIAKI) Including the Role of COVID-19

COVID-19의 역할을 포함한 횡문근 융해 유발 AKI(RIAKI)

Review

Published on 2022-07-262022-09-11
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술,

[키워드] acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration AKI aspartate Aspartate aminotransferase AST bloodstream caused Cell combination therapy Complication contribute coronavirus Course COVID-19 COVID-19 disease creatine creatine kinase damage defined develop Diagnosis disease drugs escape Factors FIVE Fluid resuscitation furosemide high mortality rate in some Including Lactate lactate dehydrogenase LDH life-threatening limit mannitol many cases marker muscle pain Myoglobin occur Pain Patient patients Potassium renal renal replacement therapy replacement therapy required respiratory rhabdomyolysis role RRT SARS-CoV-2 serious complication serum severe acute respiratory syndrome Coronavirus Side effect Side effects sodium sodium bicarbonate statin statin. Striated muscle therapeutic interventions therapy Treatment uridine
[DOI] 10.3390/ijms23158215 PMC 바로가기 [Article Type] Review

Characterization of SARS-CoV-2 Escape Mutants to a Pair of Neutralizing Antibodies Targeting the RBD and the NTD

RBD 및 NTD를 표적으로 하는 한 쌍의 중화 항체에 대한 SARS-CoV-2 탈출 돌연변이의 특성화

Article

Published on 2022-07-252022-09-11
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] active immunization Affect antibodies antibody binding Cell culture characterization Clinical use Cluster Combination Efficacy escape escape mutant escape mutants escape mutation gene segments Genetic human immunoglobulin identify immunization immunization strategies Immunoglobulin indicate lead mice monoclonal monoclonal antibodies monoclonal antibody more difficult Mutation mutations neutralization Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody nine not affected NTD pair passage pseudotype RBD RBD mutations reduced SARS-CoV-2 SARS-CoV-2 escape mutations SARS-CoV-2 variant SARS-CoV-2 variants selected Spike protein targeting the RBD the spike protein variable region variant variants variants of concern variants of concern. VoC
[DOI] 10.3390/ijms23158177 PMC 바로가기 [Article Type] Article

Immune Escape Associated with RBD Omicron Mutations and SARS-CoV-2 Evolution Dynamics

RBD 오미크론 돌연변이 및 SARS-CoV-2 진화 역학과 관련된 면역 탈출

Review

Published on 2022-07-222022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 변종,

Omicron BA.1 Mutations in SARS-CoV-2 Spike Lead to Reduced T-Cell Response in Vaccinated and Convalescent Individuals

SARS-CoV-2 스파이크의 Omicron BA.1 돌연변이는 백신 접종 및 회복기 개인의 T-세포 반응 감소로 이어집니다

Article

Published on 2022-07-192022-09-11
Journal: Viruses
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] alleles BNT162b2 BNT162b2 vaccine CD4 CD4+ T-cell CD4+ T-cell epitopes cellular immunity circulating cross-reactive cross-reactivity elicited Epitopes escape facilitated help HLA HLA class II HLA class II alleles HLA motif prediction immune Immune escape immunodominant epitope immunodominant epitopes individual infect loss of memory memory monitoring motif mRNA mRNA-based Mutation mutations natural infection Neutralizing antibodies omicron Omicron BA.1 variant predict predicted preserved reactivity response SARS-CoV-2 SARS-CoV-2 immunity selected spike Spike protein spike-protein strain T cell T cells T-cell T-cell epitope T-cell epitopes T-cell Response T-cell responses the spike protein vaccination vaccination. variant virus variant virus variants
[DOI] 10.3390/v14071570 PMC 바로가기 [Article Type] Article

Integrating Conformational Dynamics and Perturbation-Based Network Modeling for Mutational Profiling of Binding and Allostery in the SARS-CoV-2 Spike Variant Complexes with Antibodies: Balancing Local and Global Determinants of Mutational Escape Mechanisms

항체가 있는 SARS-CoV-2 스파이크 변이체 복합체에서 결합 및 알로스테리의 돌연변이 프로파일링을 위한 형태 역학 및 섭동 기반 네트워크 모델링 통합: 돌연변이 탈출 메커니즘의 로컬 및 글로벌 결정인자 균형 조정

Article

Published on 2022-07-102022-09-11
Journal: Biomolecules
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] Affect allosteric communication Analysis antibodies antibody Antibody binding antibody combination antibody escape approach balancing binding binding affinity binding energy binding hotspots binding interaction change Complexes complexes conformational conformational dynamics conserved cross-reactive determinant determined by dominant dynamic network modeling Dynamics Effect Efficiency energetics escape escape mutant escape mutants Factors flexibility fluctuation host receptor identify Interaction interactions Local MD simulations mechanism modeling modulate Mutation mutational profiling mutations network neutralization neutralize omicron pattern predict Profiling Protein protein folding protein stability residue SARS-CoV-2 spike SARS-CoV-2 spike protein single antibody spike spike plasticity Spike protein stability suggested the antibody the SARS-CoV-2 ultrapotent antibodies. variant
[DOI] 10.3390/biom12070964 PMC 바로가기 [Article Type] Article

Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5

SARS-CoV-2 오미크론 변종 BA.2.12.1, BA.4 및 BA.5에 의한 중화 탈출

Article

Published on 2022-07-072022-09-11
Journal: The New England Journal of Medicine
[Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] escape omicron SARS-CoV-2
[DOI] 10.1056/NEJMc2206576 PMC 바로가기 [Article Type] Article